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Reif Genealogie Ausrichtung polymerase kappa inhibitor Führung Amplitude Hilflosigkeit

Structural Basis for Human DNA Polymerase Kappa to Bypass Cisplatin  Intrastrand Cross-Link (Pt-GG) Lesion as an Efficient and Accurate Extender  - ScienceDirect
Structural Basis for Human DNA Polymerase Kappa to Bypass Cisplatin Intrastrand Cross-Link (Pt-GG) Lesion as an Efficient and Accurate Extender - ScienceDirect

DNA polymerase eta: A potential pharmacological target for cancer therapy -  Saha - 2021 - Journal of Cellular Physiology - Wiley Online Library
DNA polymerase eta: A potential pharmacological target for cancer therapy - Saha - 2021 - Journal of Cellular Physiology - Wiley Online Library

A Small-Molecule Inhibitor of Human DNA Polymerase η Potentiates the  Effects of Cisplatin in Tumor Cells | Biochemistry
A Small-Molecule Inhibitor of Human DNA Polymerase η Potentiates the Effects of Cisplatin in Tumor Cells | Biochemistry

Frontiers | Inhibiting DNA Polymerases as a Therapeutic Intervention  against Cancer
Frontiers | Inhibiting DNA Polymerases as a Therapeutic Intervention against Cancer

IJMS | Free Full-Text | Detours to Replication: Functions of Specialized  DNA Polymerases during Oncogene-induced Replication Stress | HTML
IJMS | Free Full-Text | Detours to Replication: Functions of Specialized DNA Polymerases during Oncogene-induced Replication Stress | HTML

DNA polymerase κ: Friend or foe? | Science Signaling
DNA polymerase κ: Friend or foe? | Science Signaling

Translesion polymerase kappa-dependent DNA synthesis underlies replication  fork recovery | eLife
Translesion polymerase kappa-dependent DNA synthesis underlies replication fork recovery | eLife

DNA Polymerase Kappa Antibody (6F2) (H00051426-M01): Novus Biologicals
DNA Polymerase Kappa Antibody (6F2) (H00051426-M01): Novus Biologicals

Translesion polymerase kappa-dependent DNA synthesis underlies replication  fork recovery | eLife
Translesion polymerase kappa-dependent DNA synthesis underlies replication fork recovery | eLife

DNA polymerase eta protects human cells against DNA damage induced by the  tumor chemotherapeutic temozolomide - ScienceDirect
DNA polymerase eta protects human cells against DNA damage induced by the tumor chemotherapeutic temozolomide - ScienceDirect

Science Signaling - The DNA polymerase Pol-kappa endows tumor cells with  resistance to the BRAF inhibitor vemurafenib without increasing  mutagenesis, according to new research from the White lab.  https://fcld.ly/5jaum2s Credit: K. Temprine
Science Signaling - The DNA polymerase Pol-kappa endows tumor cells with resistance to the BRAF inhibitor vemurafenib without increasing mutagenesis, according to new research from the White lab. https://fcld.ly/5jaum2s Credit: K. Temprine

Regulation of the error-prone DNA polymerase Polκ by oncogenic signaling  and its contribution to drug resistance | Science Signaling
Regulation of the error-prone DNA polymerase Polκ by oncogenic signaling and its contribution to drug resistance | Science Signaling

DNA Polymerase Kappa Research Products: Novus Biologicals
DNA Polymerase Kappa Research Products: Novus Biologicals

Inhibition of mutagenic translesion synthesis: A possible strategy for  improving chemotherapy? | PLOS Genetics
Inhibition of mutagenic translesion synthesis: A possible strategy for improving chemotherapy? | PLOS Genetics

NF-κB inhibitors in treatment and prevention of lung cancer - ScienceDirect
NF-κB inhibitors in treatment and prevention of lung cancer - ScienceDirect

Inhibition of Human DNA Polymerases Eta and Kappa by Indole-Derived  Molecules Occurs through Distinct Mechanisms
Inhibition of Human DNA Polymerases Eta and Kappa by Indole-Derived Molecules Occurs through Distinct Mechanisms

DNA polymerases and cancer | Nature Reviews Cancer
DNA polymerases and cancer | Nature Reviews Cancer

Anti-DNA Polymerase Kappa/POLK antibody (ab86076) | Abcam
Anti-DNA Polymerase Kappa/POLK antibody (ab86076) | Abcam

A Comprehensive Strategy to Discover Inhibitors of the Translesion  Synthesis DNA Polymerase κ | PLOS ONE
A Comprehensive Strategy to Discover Inhibitors of the Translesion Synthesis DNA Polymerase κ | PLOS ONE

Translesion polymerase kappa-dependent DNA synthesis underlies replication  fork recovery | eLife
Translesion polymerase kappa-dependent DNA synthesis underlies replication fork recovery | eLife

DNA polymerase eta: A potential pharmacological target for cancer therapy -  Saha - 2021 - Journal of Cellular Physiology - Wiley Online Library
DNA polymerase eta: A potential pharmacological target for cancer therapy - Saha - 2021 - Journal of Cellular Physiology - Wiley Online Library

DNA polymerase eta: A potential pharmacological target for cancer therapy -  Saha - 2021 - Journal of Cellular Physiology - Wiley Online Library
DNA polymerase eta: A potential pharmacological target for cancer therapy - Saha - 2021 - Journal of Cellular Physiology - Wiley Online Library

Frontiers | Inhibiting DNA Polymerases as a Therapeutic Intervention  against Cancer
Frontiers | Inhibiting DNA Polymerases as a Therapeutic Intervention against Cancer

Inhibition of mutagenic translesion synthesis: A possible strategy for  improving chemotherapy? | PLOS Genetics
Inhibition of mutagenic translesion synthesis: A possible strategy for improving chemotherapy? | PLOS Genetics

Translesion polymerase eta both facilitates DNA replication and promotes  increased human genetic variation at common fragile sites | PNAS
Translesion polymerase eta both facilitates DNA replication and promotes increased human genetic variation at common fragile sites | PNAS

RCSB PDB - 6BS1: Crystal Structure of Human DNA polymerase kappa in complex  with DNA containing the major cisplatin lesion
RCSB PDB - 6BS1: Crystal Structure of Human DNA polymerase kappa in complex with DNA containing the major cisplatin lesion

DNA polymerase η promotes nonhomologous end joining upon etoposide exposure  dependent on the scaffolding protein Kap1 - Journal of Biological Chemistry
DNA polymerase η promotes nonhomologous end joining upon etoposide exposure dependent on the scaffolding protein Kap1 - Journal of Biological Chemistry

Phosphorylation Alters the Properties of Pol η: Implications for  Translesion Synthesis
Phosphorylation Alters the Properties of Pol η: Implications for Translesion Synthesis